Position Title
Adjunct Professor
Position Title
Adjunct Professor
- Molecular and Cellular Biology
- Pharmacology
3253 Green Hall
Bio
Research Interests
My lab studies molecular motors, protein synthesis on the ribosome and RNA helicases using novel biophysical techniques. We develop new methods particularly in single molecule biophysics, such as fluorescent particle tracking, high-speed optical traps, and polarized total internal reflection fluorescence (polTIRF) microscopy to quantify the structural dynamics of rotational motions of the target proteins and to delineate the mechanisms of enzymatic and energy transformation reactions.
Education and Degree(s)
- 1969 B.S. in Electrical Engineering, Northwestern University
- 1975 M.D., University of Pennsylvania
- 1975 Ph.D. in Physiology, University of Pennsylvania
- 1975 - 1979, Postdoctoral Fellow with Andrew F. Huxley and Robert M. Simmons, University College London
Publications
- Yanas A, Shweta H, Owens MC, Liu KF, Goldman YE. RNA helicases DDX3X and DDX3Y form nanometer-scale RNA-protein clusters that support catalytic activity. Curr Biol. 2024 Dec 16;34(24):5714-5727.e6. doi: 10.1016/j.cub.2024.10.055. Epub 2024 Nov 25. PMID: 39591970.
- Chen C, Cui X, Beausang JF, Zhang H, Farrell I, Cooperman BS, Goldman YE. Elongation factor G initiates translocation through a power stroke. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7515-20. doi: 10.1073/pnas.1602668113. Epub 2016 Jun 16. PMID: 27313204; PMCID: PMC4941437.
- Yildiz A, Forkey JN, McKinney SA, Ha T, Goldman YE, Selvin PR. Myosin V walks hand-over-hand: single fluorophore imaging with 1.5-nm localization. Science. 2003 Jun 27;300(5628):2061-5. doi: 10.1126/science.1084398. Epub 2003 Jun 5. PMID: 12791999.
- Forkey JN, Quinlan ME, Shaw MA, Corrie JE, Goldman YE. Three-dimensional structural dynamics of myosin V by single-molecule fluorescence polarization. Nature. 2003 Mar 27;422(6930):399-404. doi: 10.1038/nature01529. PMID: 12660775.
- Hibberd MG, Dantzig JA, Trentham DR, Goldman YE. Phosphate release and force generation in skeletal muscle fibers. Science. 1985 Jun 14;228(4705):1317-9. doi: 10.1126/science.3159090. PMID: 3159090.