Biochemistry, Molecular, Cellular and Developmental Biology Graduate Group

Study Highlights Molecular Targets Integral to Breast Cancer Treatment

It’s estimated that over 281,000 women in the U.S. will be diagnosed with breast cancer this year, according to the National Cancer Institute. And about one in seven women will receive a breast cancer diagnosis in their lifetime.

For those with breast cancer gene 2 (BRCA2) mutations, the risk of developing breast cancer is much higher. Between 45 and 69 percent of those with this genetic mutation will develop breast cancer by 70 to 80 years of age. 

A Map of Mouse Brain Metabolism in Aging

The first atlas of metabolites in the mouse brain has been published by a team led by UC Davis researchers. The dataset includes 1,547 different molecules across 10 brain regions in male and female laboratory mice from adolescence through adulthood and into advanced old age. The work is published Oct. 15 in the Nature Communications. The complete dataset is publicly available at https://mouse.atlas.metabolomics.us/.

UC Davis Researchers Among Successful PREP Scholars Admitted to Campus Graduate Programs

Four UC Davis postbaccalaureate researchers returned to campus this fall as both graduate students and fellows of the prestigious National Science Foundation (NSF) Graduate Research Fellowship Program (GRFP). The NSF GRFP supports outstanding scholars in STEM fields, providing a three-year annual stipend of $34,000 along with a $12,000 cost of education allowance for tuition and fees.

Researchers Identify a Potentially Safer Approach to Opioid Drug Development

Opioids are powerful painkillers but their use is hindered because patients become tolerant to them, requiring higher and higher doses, and overdoses can cause respiratory depression and death. A recent study from researchers at the UC Davis Center for Neuroscience contradicts existing thinking about how opioid drugs cause tolerance and respiratory depression, and suggests a new, balanced approach to developing safer analgesics. The work was published July 13 in Neuropsychopharmacology.

Interrupting the Development of Cancer Cells

Think of chromosomes as nature’s shoelaces. Built from DNA, these thread-like structures carry and ferry the genetic information necessary for life. To maintain genetic integrity, chromosomes possess protective structures located at their ends called telomeres. These telomeres are like the plastic tips of shoelaces, preventing the genetic thread from unraveling as cells continuously divide.

$2 Million NIH Grant Expands Grad Program for Underrepresented Students

Aldrin Gomes, a professor in the Departments of Neurobiology, Physiology and Behavior, and Physiology and Membrane Biology, can still recall the reality he faced when he came to the United States to conduct postdoctoral research. Growing up in Trinidad and Tobago, Gomes was accustomed to the cultural diversity of the island. But shortly after stepping on American soil, he started experiencing things he didn’t understand.

$1 Million Keck Foundation Grant Backs Research to "Build a Brain"

A team of scientists from UC Davis and Rice University are starting small as they begin to figure out how to build an artificial brain from the bottom up.

Celina Juliano, an associate professor in the Department of Molecular and Cellular Biology, and Jacob Robinson of Rice University’s Brown School of Engineering have won a $1 million Keck Foundation grant to advance the team’s synthetic neurobiology effort to define the connections between neurons and muscles that drive programmed behaviors in living animals.