A new study shows exactly how the gene BRCA2, linked to susceptibility to breast and ovarian cancer, functions to repair damaged DNA. By studying BRCA2 at the level of single molecules, researchers at the University of California, Davis, have generated new insights into the mechanisms of DNA repair and the origins of cancer. The work was published the week of March 27 in the Proceedings of the National Academy of Sciences.
The Greek hero Heracles fought a monster called the Hydra, which grew two new heads for each one he lopped off. Heracles was lucky he wasn’t fighting something with the regenerative ability of the real Hydra, which can re-grow its entire body from a few hundred cells. This simple water animal is helping scientists explore how some animals can regrow missing body parts.
Back-to-back papers in the Dec. 29 issue of Nature Plants report the first complete protein structures for plant respiratory supercomplex I+III₂. Obtaining these structures helps researchers understand basic plant biology, as well as stress responses and how biofuel crops might grow more rapidly.
Female infants are born with several million immature egg cells, or oocytes. Over the course of the reproductive years, a few hundred of them will develop into mature eggs for potential fertilization. Because of this extended maturation process, the oocytes of humans and other mammals are vulnerable to both developmental exposures and the aging process.
Chemical engineer and microbiologist Priya Shah is unraveling the essential aspects of arboviruses - viruses transmitted by mosquitoes, ticks, or other arthropods - aiming to thwart this major source of emerging diseases by identifying novel therapeutic targets.
For her innovative research, she has been awarded $40,000 from a UC Davis endowment set up by anonymous donors. The awards, given annually since 2016, are designated for non-tenured ladder-track faculty.
Plants photosynthesize to survive, and bacteria divide to reproduce, but to accomplish these necessary biological functions, the cells of these organisms employ protein trafficking. More specifically, these functionalities, among many others, rely on the twin-arginine translocation (Tat) pathway, which, when properly functioning, allows for the transportation of proteins across cellular membranes.
The college is very pleased to welcome the newest members of its broad and diverse faculty. With appointments in the Departments of Evolution and Ecology, Plant Biology and Microbiology and Molecular Genetics, the new faculty are poised to make an impact on their respective areas of expertise, and on the classroom and laboratory experience of our students across the college.
Anya Brown
Assistant Professor Department of Evolution and Ecology
The success of E. coli bacteria depends on their ability to multiply very rapidly by dividing into new cells. The bacteria can divide as quickly as they can make an entire new copy of their DNA while minimizing errors. New work from researchers at the University of California, Davis College of Biological Sciences answers a key question about how E. coli fixes damage to DNA in the middle of duplicating it.
The U.S. Department of Energy is funding a project at the UC Davis College of Biological Sciences to study the function of genes that regulate growth and wood formation in poplar trees. The three-year, $2.5 million project is led by Nitzan Shabek, assistant professor in the UC Davis Department of Plant Biology together with Andrew Groover at the USDA Pacific Southwest Research Station in Davis and Justin Walley, Iowa State University.
